Steady-fiber granule (SFG) is a functional food mixture that is composed of four major ingredients, resistant maltodextrin, white kidney bean (Phaseolus vulgaris) extract, mulberry leaf (Morus alba L.) extract, and niacin-bound chromium complex. This study focused on determining the safety of SFG. Nature's Way Pure Chromium Polynicotinate (Niacin Bound) 200mcg 100 Caps TV Doctor Customers: This product was talked about on The TV Doctor Show to help lower blood pressure, heal inflammation and lose weight. This Chromium Polynicotinate provides 200mcg per capsule, just as TV Show Doctor recommended per day.
|Other names||Chromium trinicotinate|
|Chemical and physical data|
|Molar mass||418.305 g·mol−1|
|3D model (JSmol)|
Chromium(III) nicotinate is an ionic substance used for chromium supplementation in some nutritional products, where it is also referred to as chromium polynicotinate. It appears in products that are referred to as a medical food used for nutritional support for conditions associated with diabetes mellitus type 2. The product is also known as 'niacin-bound chromium'.
Chromium(III) nicotinate contains three nicotinic acid units per chromium ion; that is, it is the trinicotinate of chromium(III). The substance that is used in supplements and called 'chromium polynicotinate' is said to be a mixture of the trinicotinate and the dinicotinate, with the former dominating.
- ^Preuss HG, Bagchi D, Bagchi M, Rao CV, Dey DK, Satyanarayana S (May 2004). 'Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss'. Diabetes, Obesity & Metabolism. 6 (3): 171–80. doi:10.1111/j.1462-8902.2004.00328.x. PMID15056124.
- ^European Food Safety Authority (EFSA) (2008). 'Mixture of chromium di- and tri-nicotinate as a source of chromium added for nutritional purposes in food supplements and in foods for particular nutritional uses'. The EFSA Journal. 887: 1–24. doi:10.2903/j.efsa.2008.887.
People use gymnema for diabetes, weight loss, and other conditions, but there is no good scientific evidence to support these uses.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The effectiveness ratings for GYMNEMA are as follows:
Insufficient evidence to rate effectiveness for...
Chromium Polynicotinate 200mcg Benefits
- Diabetes. Early research shows that taking gymnema by mouth along with insulin or diabetes medications can improve blood sugar control in people with type 1 or type 2 diabetes.
- Metabolic syndrome. Early research shows that taking gymnema for 12 weeks can reduce body weight and body mass index in overweight people with metabolic syndrome. But gymnema does not appear to help with blood sugar control or improve cholesterol levels in these people.
- Weight loss. Early research shows that taking gymnema for 12 weeks can reduce body weight and body mass index in some people who are overweight. Early research also shows that taking a combination of gymnema, hydroxycitric acid, and niacin-bound chromium by mouth can reduce body weight in people who are overweight or obese.
- Increasing urine excretion (diuretic).
- Metabolic syndrome.
- Snake bites.
- Softening the stool (laxative).
- Stimulating digestion.
Special precautions & warnings:Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking gymnema if you are pregnant or breast feeding. Stay on the safe side and avoid use.
Diabetes: Gymnema can lower blood sugar levels in people with diabetes. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use gymnema.
Surgery: Gymnema might affect blood sugar levels and could interfere with blood sugar control during and after surgical procedures. Stop using gymnema at least 2 weeks before a scheduled surgery.
- Be cautious with this combination.
- Gymnema might decrease blood sugar. Insulin is also used to decrease blood sugar. Taking gymnema along with insulin might cause your blood sugar to be too low. Monitor your blood sugar closely. The dose of your insulin might need to be changed.
- Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)
- Some medications are changed and broken down by the liver. Gymnema might decrease how quickly the liver breaks down some medications. Taking gymnema along with some medications that are changed and broken down by the liver might increase the effects and side effects of some medications. Before taking gymnema, talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.
- Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)
- Some medications are changed and broken down by the liver. Gymnema might change how quickly the liver breaks down some medications. Taking gymnema along with some medications that are changed and broken down by the liver might change the effects and side effects of some medications. Before taking gymnema, talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.
- Medications for diabetes (Antidiabetes drugs)
- Gymnema supplements seem to lower blood sugar in people with diabetes. Diabetes medications are also used to lower blood sugar. Taking gymnema along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
- The body breaks down phenacetin to get rid of it. Gymnema might decrease how quickly the body breaks down phenacetin. Taking gymnema while taking phenacetin might increase the effects and side effects of phenacetin. Before taking gymnema, talk to your healthcare provider if you are taking phenacetin.
- The body breaks down tolbutamide to get rid of it. Gymnema might increase how quickly the body breaks down tolbutamide. Taking gymnema while taking tolbutamide might decrease the effects of tolbutamide. Before taking gymnema, talk to your healthcare provider if you are taking tolbutamide.
- Be watchful with this combination.
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
- Some medications are changed and broken down by the liver. Gymnema might decrease how quickly the liver breaks down some medications. Taking gymnema along with some medications that are changed by the liver might increase the effects and side effects of some medications. Before taking gymnema, talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include lovastatin (Mevacor), clarithromycin (Biaxin), cyclosporine (Neoral, Sandimmune), diltiazem (Cardizem), estrogens, indinavir (Crixivan), triazolam (Halcion), and many others.
Are there interactions with herbs and supplements?
- Herbs and supplements that might lower blood sugar
- Gymnema extract might lower blood sugar. Using it with other herbs and supplements that have this same effect might increase the risk of low blood sugar in some people. Some of these products include alpha-lipoic acid, bitter melon, chromium, devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, Siberian ginseng, and others.
- Oleic acid
- Gymnema might decrease the body's absorption of oleic acid.
Niacin Bound Chromium Vs Chromium Picolinate
To learn more about how this article was written, please see the Natural Medicines Comprehensive Databasemethodology.
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